First International p53 Isoforms Meeting: ‘p53 isoforms through evolution: from identification to biological function’
نویسندگان
چکیده
منابع مشابه
p53 isoforms change p53 paradigm
Although p53 defines cellular responses to cancer treatment it is not clear how p53 can be used to control cell fate outcome. Data demonstrate that so-called p53 does not exist as a single protein, but is in fact a group of p53 protein isoforms whose expression can be manipulated to control the cellular response to treatment.
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p53 is a transcription factor with capability of regulating diverse NF-κB dependent biological progresses such as inflammation and host defense, but the actual mechanism remains unrevealed. Herein, we firstly identified two novel alternatively spliced isoforms of p53 from Litopenaeus vannamei (LvΔNp53 and the full-length of p53, LvFLp53). We then established that the two p53 isoforms exerted op...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2010
ISSN: 1350-9047,1476-5403
DOI: 10.1038/cdd.2010.156